Outcomes in children with down syndrome and mild obstructive sleep apnea treated non‐surgically
| Autor: | Raisa Tikhtman, Wenwen Yu, Stacey L. Ishman, David F. Smith, Kathleen M. Sarber, Javier J M Howard, Narong Simakajornboon |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Down syndrome Adolescent Supplemental oxygen Polysomnography Conservative Treatment Severity of Illness Index Article 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine Humans Medicine Child Prospective cohort study Oxyhemoglobin saturation Retrospective Studies Sleep Apnea Obstructive business.industry Infant medicine.disease respiratory tract diseases Obstructive sleep apnea Otorhinolaryngology Child Preschool Cohort Female Down Syndrome Sleep business 030217 neurology & neurosurgery After treatment Follow-Up Studies |
| Zdroj: | Laryngoscope |
| ISSN: | 1531-4995 0023-852X |
| DOI: | 10.1002/lary.28325 |
| Popis: | OBJECTIVES: Nasal steroids, oral anti-leukotrienes and supplemental oxygen are effective in the treatment of mild obstructive sleep apnea (OSA) in otherwise healthy children. However, their efficacy is unknown in children with Down syndrome (DS). Here we examine the effect of single medication therapy versus observation versus oxygen on polysomnographic outcomes in these children. METHODS: We reviewed children (50 mmHg. RESULTS: Twenty-four children met inclusion criteria; 10 treated with medication, one with oxygen, and 13 with observation (baseline oAHI was 3.5, 3.3, and 2.9 events/hour, respectively). There was no significant change in oAHI, oxyhemoglobin saturation nadir, ETCO(2), or percent TST in REM after treatment for any treatment group (P = .21–.94). There was no association between reported symptoms and AHI severity or change in AHI. OSA resolved in one patient treated with observation and two treated with medication, but worsened in two each in the medication and observation groups. Resolution of OSA occurred in 20% treated with medication, 7.7% with observation, and 0% with oxygen (P = .82). CONCLUSION: In our cohort, resolution of mild OSA was low. This suggests that consideration should be given to multimodality treatments in children with DS and mild OSA. Prospective studies will help establish effectiveness in this cohort. |
| Databáze: | OpenAIRE |
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