Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia
| Autor: | Yuko Watanabe, Shigeru Tsuchiya, Satoshi Horino, Yoji Sasahara, Yutaka Hayashi, Yoshiyuki Hoshi, Masaei Onuma, Miyako Yoshinari, Takeshi Rikiishi, Takuro Kazama, Hiroshi Abe, Hidetaka Niizuma, Satoru Kumaki |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Vincristine medicine.medical_treatment Chronic lymphocytic leukemia Splenectomy Gastroenterology Maintenance therapy immune system diseases hemic and lymphatic diseases Internal medicine Acute lymphocytic leukemia Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Chemotherapy Purpura Thrombocytopenic Idiopathic business.industry Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Thrombocytopenic purpura Treatment Outcome Immunology Chronic Disease Rituximab Female business medicine.drug |
| Zdroj: | International journal of hematology. 90(4) |
| ISSN: | 1865-3774 |
| Popis: | Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient. |
| Databáze: | OpenAIRE |
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