Lung Cancer in Patients with HIV Infection and Review of the Literature
| Autor: | Marie-Ange Massiani, Jean-Luc Breau, David Khayat, Sylvie Friard, Christine Katlama, Jean-François Morère, Philippe Bossi, Olivier Rixe, Louis-Jean Couderc, François Rouges, Michele Bentata, Jean-Philippe Spano |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Substance-Related Disorders MEDLINE Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Risk Factors Internal medicine Humans Medicine In patient Age of Onset Lung cancer Retrospective Studies Hematology business.industry Smoking Cancer Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Immunology Female Age of onset business |
| Zdroj: | Medical Oncology. 21:109-116 |
| ISSN: | 1357-0560 |
| DOI: | 10.1385/mo:21:2:109 |
| Popis: | The improved survival of patients since the use of highly active antiretroviral treatments has lead to the reporting of non-AIDS defining tumors, such as lung cancer.Analysis of the records of 22 HIV-infected patients with lung cancer (LC) diagnosed in three hospitals located in the Paris area (France).Twenty-one patients were smokers. The patients (86% male, 14% female) had a median age of 45 yr (range, 33-64 yr). Risk factors for HIV infection were intravenous drug use in 5 patients, homosexual transmission in 10 patients, and heterosexual transmission in 7 patients. At diagnosis of LC, seven patients had previously developed a CDC-defined AIDS manifestation, the median CD4 cell count was 364/mm3 (range 20-854/mm3) and median HIV1 RNA viral load was 3000 copies/mL. The most frequent histological subtype was squamous cell carcinoma (11 cases). A stage III-IV disease was observed in 75% of the patients. Only one patient had a small-cell lung carcinoma. Twenty-one patients received combined specific therapy, of which six patients underwent surgery for the LC. The median overall survival was 7 mo. No opportunistic infections occurred during LC therapy.LC occurs at a young age in HIV-infected smokers. LC is not associated with severe immunodeficiency. The prognosis is poor because of their initial extensive disease and a poor response to therapy. However, surgery appears to improve outcome in much the same way as in the general population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink