Reintroduction of Cow’s Milk in Milk-Allergic Children: Safety and Risk Factors
| Autor: | Emmanuel Manoussakis, Photini Saxoni-Papageorgiou, Dimitrios Kassimos, Emilia Vassilopoulou, Nikolaos Douladiris, Nikolaos G. Papadopoulos, George N. Konstantinou, Paraskevi Xepapadaki |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Allergy Urticaria Gastrointestinal Diseases Immunology Cow milk Food allergy Respiratory Hypersensitivity Animals Humans Immunology and Allergy Medicine Angioedema Risk factor Child Retrospective Studies Skin Tests business.industry Infant Newborn Infant food and beverages General Medicine Skin test Immunoglobulin E medicine.disease Milk Child Preschool Female Milk Hypersensitivity business |
| Zdroj: | International Archives of Allergy and Immunology. 146:156-161 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000113519 |
| Popis: | Background: Although development of clinical tolerance is the rule in allergy to cow’s milk (CM), food challenges are required in order to reintroduce CM into the patient’s diet. Less ‘invasive’ procedures able to predict tolerance would be useful as clinical tools. The purpose of this study was to identify potential risk factors for clinical reactivity in CM-allergic children assessed for CM reintroduction. Methods: One hundred and sixteen open challenges performed in children 10–47 months old with IgE-mediated allergy to CM, in order to reintroduce CM into the diet, were retrospectively evaluated. Specific IgE (sIgE) levels assessed by the CAP System FEIA and skin prick tests (SPT) were obtained at diagnosis and prechallenge. Demographic parameters and measures of sIgE were evaluated as potential predictors of a positive challenge in univariate and multivariate logistic regression models. Results: Twenty-four out of 116 challenges were positive, 9 of which required the use of adrenaline. In order of performance, prechallenge sIgE 7.5 mm or sIgE >25.4 kU/l, or their combination, had a high positive predictive value. The presence of atopic dermatitis did not affect the predictive accuracy of these values. Conclusions: Milk sIgE level prechallenge is a useful predictor of challenge outcome in patients with milk allergy. SPT do not offer an additional predictive value, but can be used when sIgE is not available. |
| Databáze: | OpenAIRE |
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