An autopsy case of anaplastic lymphoma kinase-positive lung cancer exacerbated in a short period of time: a case report
| Autor: | Kazuhiro Sato, Naho Kumagai, Yuji Okuda, Maya Suzuki, Sho Sakamoto, Yuka Izumiya, Masaaki Sano, Kazuhisa Sudo, Masahide Takeda, Katsutoshi Nakayama, Yasufumi Omori, Mariko Asano |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Alectinib
Adult Pathology medicine.medical_specialty Lung Neoplasms Anaplastic Lymphoma Adenosquamous carcinoma lcsh:Medicine Case Report 030204 cardiovascular system & hematology 03 medical and health sciences Carcinoma Adenosquamous 0302 clinical medicine Papillary adenocarcinoma Fatal Outcome Surgical oncology ALK-positive adenosquamous carcinoma hemic and lymphatic diseases medicine Anaplastic lymphoma kinase Humans Anaplastic Lymphoma Kinase Lung cancer Crizotinib business.industry Brain Neoplasms lcsh:R General Medicine medicine.disease ALK-positive lung cancer 030220 oncology & carcinogenesis Autopsy business medicine.drug |
| Zdroj: | Journal of Medical Case Reports, Vol 13, Iss 1, Pp 1-5 (2019) Journal of Medical Case Reports |
| ISSN: | 1752-1947 |
| DOI: | 10.1186/s13256-019-2054-3 |
| Popis: | Background Anaplastic lymphoma kinase-positive lung cancer is a form of lung cancer that accounts for approximately 5% of non-small cell lung cancers. Recently, anaplastic lymphoma kinase inhibitors have been used for treatment of anaplastic lymphoma kinase-positive lung cancer, and their high clinical effect has also been demonstrated in cases of advanced stage lung cancer. Alectinib is an anaplastic lymphoma kinase inhibitor that it is recognized as a standard drug for primary therapy because of its superiority to crizotinib. Case presentation A 37-year-old Japanese man was admitted to our hospital due to multiple brain metastases. An autopsy report revealed that the cause of death was anaplastic lymphoma kinase-positive lung cancer, exacerbated in a short period despite treatment with alectinib. Necropsy revealed anaplastic lymphoma kinase-positive adenosquamous carcinoma of the lung, suggesting that it was involved in the prognosis of this patient. Based on the autopsy results, we reviewed the pathological tissue from transbronchial lung biopsy at the time of clinical diagnosis. The tissue specimen for clinical diagnosis in this case was a papillary adenocarcinoma. However, when this tissue was immunostained, thyroid transcription factor 1-negative and cytokeratin 5/6-positive parts were recognized. This result indicates that we could diagnose this patient as having had adenosquamous carcinoma of the lung. Conclusion In cases of anaplastic lymphoma kinase-positive lung cancer poorly responsive to anaplastic lymphoma kinase inhibitors, re-examination of the tissue should be considered because there is a possibility of anaplastic lymphoma kinase-positive adenosquamous carcinoma. |
| Databáze: | OpenAIRE |
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