INFLUENCE OF PROPHYLACTIC TREATMENT WITH γ-IMMUNOGLOBULINS ON RENAL FUNCTION AFTER KIDNEY TRANSPLANTATION IN RHESUS MONKEYS
| Autor: | R. L. Marquet, G. G. Persijn, Z. De By-Aghai, H. Balner, J. C. C. Borleffs, R. E. Dolkart |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Prednisolone Renal function Azathioprine Gastroenterology chemistry.chemical_compound Internal medicine medicine Animals Humans Adverse effect Kidney transplantation Transplantation Creatinine Kidney business.industry Histocompatibility Testing Graft Survival medicine.disease Kidney Transplantation Macaca mulatta medicine.anatomical_structure chemistry Immunoglobulin G Female business medicine.drug |
| Zdroj: | Transplantation. 33:27-30 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-198201000-00006 |
| Popis: | The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated animals had been given three pretransplant blood transfusions, graft survival ranged from 9 to 61 days with 42% of the animals showing a prolonged survival time (greater than 22 days). However, in both transfused and nontransfused recipients, the additional pretransplant administration of IgG appeared to have an adverse effect: about 25% of the animals showed accelerated rejection. In addition, serum creatinine levels in IgG-treated recipients were significantly higher on the 3rd day after transplantation than in non-treated monkeys. We concluded that renal transplant patients should be treated with IgG for protection against life-threatening infections only if they have good kidney function. |
| Databáze: | OpenAIRE |
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