Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells
| Autor: | Shinn Zong Lin, Hung Li, Yi Shiuan Tzeng, Pao Sheng Yen, Hui I. Yang, Woei Cherng Shyu, Cheng-Yoong Pang |
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| Rok vydání: | 2004 |
| Předmět: |
DNA Replication
Male medicine.medical_specialty Receptors CXCR4 Injections Subcutaneous Drug Evaluation Preclinical Infarction Neovascularization Physiologic Rats Sprague-Dawley Bone Marrow Physiology (medical) Internal medicine Granulocyte Colony-Stimulating Factor medicine Animals Cell Lineage Stroke Hematopoietic Stem Cell Mobilization Brain Chemistry Neuronal Plasticity Cerebral infarction business.industry Neurogenesis Cell Differentiation Infarction Middle Cerebral Artery Recovery of Function medicine.disease Hematopoietic Stem Cells Granulocyte colony-stimulating factor Rats Up-Regulation Haematopoiesis Endocrinology Head Movements Immunology Stem cell Cardiology and Cardiovascular Medicine business Biomarkers Cell Division Locomotion |
| Zdroj: | Circulation. 110(13) |
| ISSN: | 1524-4539 |
| Popis: | Background— Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists. Methods and Results— Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia. Conclusions— G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization. |
| Databáze: | OpenAIRE |
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