Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings
| Autor: | Eun‐Jin Cheon, Carrie E. Bearden, Daqiang Sun, Christopher R. K. Ching, Ole A. Andreassen, Lianne Schmaal, Dick J. Veltman, Sophia I. Thomopoulos, Peter Kochunov, Neda Jahanshad, Paul M. Thompson, Jessica A. Turner, Theo G.M. van Erp |
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| Přispěvatelé: | Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep |
| Rok vydání: | 2022 |
| Předmět: |
Bipolar Disorder
Clinical Sciences Article Clinical Research 2.3 Psychological Genetics DiGeorge Syndrome 2.1 Biological and endogenous factors Humans Aetiology Depressive Disorder Depressive Disorder Major major depressive disorder Depression General Neuroscience ENIGMA Neurosciences Major Brain General Medicine velocardiofacial Serious Mental Illness Magnetic Resonance Imaging Brain Disorders schizophrenia Psychiatry and Mental health Mental Health Diffusion Tensor Imaging Neurology Schizophrenia Biomedical Imaging Cognitive Sciences Neurology (clinical) social and economic factors |
| Zdroj: | Psychiatry and Clinical Neurosciences, 76(5), 140-161. Wiley-Blackwell Publishing Ltd Psychiatry Clin Neurosci Psychiatry and clinical neurosciences, vol 76, iss 5 Cheon, E-J, Bearden, C E, Sun, D, Ching, C R K, Andreassen, O A, Schmaal, L, Veltman, D J, Thomopoulos, S I, Kochunov, P, Jahanshad, N, Thompson, P M, Turner, J A & van Erp, T G M 2022, ' Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome : A review of ENIGMA findings ', Psychiatry and Clinical Neurosciences, vol. 76, no. 5, pp. 140-161 . https://doi.org/10.1111/pcn.13337 |
| ISSN: | 1440-1819 1323-1316 |
| Popis: | This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and 22q11.2 Deletion Syndrome (22q11DS) determined by ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium investigations. We obtained ranked effect sizes for subcortical volumes, regional cortical thickness, cortical surface area, and diffusion tensor imaging abnormalities, comparing each of these disorders relative to healthy controls. In addition, the studies report on significant associations between brain imaging metrics and disorder-related factors such as symptom severity and treatments. Visual comparison of effect size profiles shows that effect sizes are generally in the same direction and scale in severity with the disorders (in the order SZ > BD > MDD). The effect sizes for 22q11DS, a rare genetic syndrome that increases the risk for psychiatric disorders, appear to be much larger than for either of the complex psychiatric disorders. This is consistent with the idea of generally larger effects on the brain of rare compared to common genetic variants. Cortical thickness and surface area effect sizes for 22q11DS with psychosis compared to 22q11DS without psychosis are more similar to those of SZ and BD than those of MDD; a pattern not observed for subcortical brain structures and fractional anisotropy effect sizes. The observed similarities in effect size profiles for cortical measures across the psychiatric disorders mimic those observed for shared genetic variance between these disorders reported based on family and genetic studies and are consistent with shared genetic risk for SZ and BD and structural brain phenotypes. |
| Databáze: | OpenAIRE |
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