Subclonal evolution of cancer-related gene mutations in p53 immunopositive patches in human skin

Autor:	Sarah Ennis, Reuben J. Pengelly, Eugene Healy, J. Theaker, Matthew J. J. Rose-Zerilli, Chester Lai, Amel Albibas, Gabrielle A. Lockett, John W. Holloway
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine musculoskeletal diseases Skin Neoplasms DNA Mutational Analysis Bowen's Disease Human skin Dermatology Biology Biochemistry Stain Article Clonal Evolution Cohort Studies 03 medical and health sciences parasitic diseases medicine Humans Basal cell carcinoma Molecular Biology Gene Skin Laser capture microdissection integumentary system Actinic keratosis fungi Cancer Cell Biology medicine.disease Keratosis Actinic 030104 developmental biology Mutation Carcinoma Squamous Cell Sunlight Cancer research lipids (amino acids peptides and proteins) Tumor Suppressor Protein p53 Skin cancer Precancerous Conditions
Popis:	Normal sun-exposed skin contains numerous epidermal patches that stain positive for p53 protein (p53 immunopositive patches; PIPs), which are considered potential early precursors of skin cancer. Whilst the TP53 gene is mutated in many PIPs, it is unclear whether PIPs contain any other cancer-related mutations. Here we report that PIPs, predominantly
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8800735c53eec60a5a47e098425163 https://eprints.soton.ac.uk/413007/ Zobrazit plný text záznamu