Rubellawus A–D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti‐NLRP3 Inflammasome Effects
| Autor: | Ruihan Zhang, Jing-Jing Zhang, Yu-Kun Pu, Qi Wang, De-Wen Bi, Yi-Man Cui, Wei-Lie Xiao, Zhang Xingjie, Xue-Wen Wu, Qiang-Qiang Shi, Xiao-Li Li, Qing Li |
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| Rok vydání: | 2020 |
| Předmět: |
Inflammasomes
Bioengineering Callicarpa 01 natural sciences Biochemistry Cell Line Structure-Activity Relationship chemistry.chemical_compound NLR Family Pyrin Domain-Containing 3 Protein Ic50 values medicine Animals Molecular Biology Traditional medicine biology 010405 organic chemistry Spectrum Analysis Inflammasome Callicarpa rubella General Chemistry General Medicine biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Isopimaric acid Molecular Medicine Diterpenes medicine.drug |
| Zdroj: | Chemistry & Biodiversity. 17 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.202000798 |
| Popis: | Four new diterpenoids, rubellawus A-D (1-4), along with three known compounds, were isolated and identified from the flowers of Callicarpa rubella. Their structures were elucidated by various spectroscopic analysis. All the compounds were screened for their anti-inflammatory activity and 14α-hydroxyisopimaric acid and isopimaric acid showed significant NLRP3 inflammasome inhibitory activity with IC50 values of 7.02 and 3.99 μM. |
| Databáze: | OpenAIRE |
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