Preorbital Carcinoma in Two Kirk's Dik-diks (Madoqua kirkii)
| Autor: | Peter Wohlsein, Johannes Junginger, K. Grützmacher, Peter Dziallas, Maren Kummerfeld, M. Kummrow |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Preorbital gland
Pathology medicine.medical_specialty Exocrine gland General Veterinary biology Soft Tissue Neoplasms Anatomy biology.organism_classification medicine.disease Pathology and Forensic Medicine Malignant transformation Madoqua kirkii Cytokeratin Cell Transformation Neoplastic Exocrine Glands medicine.anatomical_structure Antelopes Dik-dik Carcinoma Squamous Cell Carcinoma medicine Animals Immunohistochemistry |
| Zdroj: | Journal of Comparative Pathology. 148:414-418 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/j.jcpa.2012.08.005 |
| Popis: | Two Kirk's dik-diks suffered from chronic, unilateral, therapy-resistant enlargement of the preorbital gland. Computed tomographic imaging revealed a homogenous preorbital mass destroying the adjacent maxillary bone in one animal. Squamous cell carcinoma was diagnosed microscopically in both cases. Immunohistochemically, the neoplastic cells uniformly expressed cytokeratin (CK) 5/6 and CK14. Additionally, tumour cells were strongly labelled for p53 suggesting a possible role of this tumour suppressor gene in tumorigenesis. Chronic obstruction of the preorbital gland due to excessive accumulation of secretory products is considered as a likely cause of glandular and periglandular inflammation with subsequent malignant transformation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect