Evaluation of the tablets’ surface flow velocities in pan coaters
| Autor: | Andreas Altmeyer, Klaus Knop, Peter Kleinebudde, Johannes Khinast, Rok Dreu, Adrian Funke, Gregor Toschkoff |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Surface Properties Chemistry Pharmaceutical Flow (psychology) Pharmaceutical Science Baffle 02 engineering and technology Drum engineering.material 030226 pharmacology & pharmacy law.invention 03 medical and health sciences 0302 clinical medicine Coating law Composite material Borescope General Medicine Radius 021001 nanoscience & nanotechnology Angle of repose Transverse plane engineering 0210 nano-technology Tablets Biotechnology |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 106:97-106 |
| ISSN: | 0939-6411 |
| DOI: | 10.1016/j.ejpb.2016.05.022 |
| Popis: | The tablet pan coating process involves various types of transverse tablet bed motions, ranging from rolling to cascading. To preserve satisfactory results in terms of coating quality after scale-up, understanding the dynamics of pan coating process should be achieved. The aim of this study was to establish a methodology of estimating translational surface velocities of the tablets in a pan coater and to assess their dependence on the drum’s filling degree, the pan speed, the presence of baffles and the selected tablet properties in a dry bed system and during coating while varying the drum’s filling degree and the pan speed. Experiments were conducted on the laboratory scale and on the pilot scale in side-vented pan coaters. Surface movement of biconvex two-layer tablets was assessed before, during and after the process of active coating. In order to determine the tablets’ surface flow velocities, a high-speed video of the tablet surface flow was recorded via a borescope inserted into the coating drum and analysed via a cross-correlation algorithm. The obtained tablet velocity data were arranged in a linear fashion as a function of the coating drum’s radius and frequency. Velocity data obtained during coating were close to those of dry tablets after coating. The filling degree had little influence on the tablet velocity profile in a coating drum with baffles but clearly affected it in a coating drum without baffles. In most but not all cases, tablets with a lower static angle of repose had tablet velocity profiles with lower slopes than tablets with higher inter-tablet friction. This particular tablet velocity response can be explained by case specific values of tablet bed’s dynamic angle of repose. |
| Databáze: | OpenAIRE |
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