Radiolabeled antifibrin antibody in the detection of venous thrombosis: preliminary results
| Autor: | T F Schaible, Mark A. Kelley, S Meranze, H J Berger, J Brown, Harold I. Palevsky, Naresh C. Gupta, Abass Alavi, Allison D. Jatlow |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.drug_class Venography Monoclonal antibody Thrombophlebitis Fibrin Immunoglobulin Fab Fragments Humans Medicine Radiology Nuclear Medicine and imaging Radionuclide Imaging Immunoglobulin Fragments Aged Aged 80 and over biology medicine.diagnostic_test business.industry Indium Radioisotopes Antibodies Monoclonal Middle Aged medicine.disease Thrombosis Venous thrombosis Monoclonal biology.protein Female Antibody business Nuclear medicine |
| Zdroj: | Radiology. 175:79-85 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.175.1.2315506 |
| Popis: | The recent development of monoclonal antibodies against components of coagulated blood may provide new approaches to the diagnosis of venous thrombosis. Scanning with an indium-111-labeled Fab fragment of a murine monoclonal antifibrin antibody (59D8) and ascending contrast venography were performed in 33 patients. Images of the calves, popliteal fossae, thighs, and pelvis were obtained immediately, 4-6 hours, and 24 hours after injection of 2 mCi (74 MBq) of the antibody. All images were read in a blinded manner. Findings in both studies were positive in 28 patients and negative in three. In 19 patients not undergoing heparin therapy, 19 specific anatomic sites were positive on venograms and 29 were positive on antibody images (19 sites matched). In 14 patients undergoing heparin therapy, 34 sites were positive on venograms and 27 were positive on antibody images (22 sites matched). In most patients, positive results were noted within 1 hour of antibody injection. No adverse effects were noted with the antibody preparation. Preliminary data suggest that antifibrin antibody imaging is sensitive in detecting clots, is safe to use, and may have a role in diagnosing and managing venous thrombosis. |
| Databáze: | OpenAIRE |
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