Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases
| Autor: | Fabian Lötscher, German Ott, Timo Gaiser, Peter Hollaus, Philipp Ströbel, Stefan Porubsky, Burkhard Möller, Zoran V. Popovic, Michaela Kotrova, Monika Brüggemann, Christian Kugler, Andreas Kreft, Yara Banz, Andreas Rosenwald, Sunil Badve, Dietmar Borchert, Sabina Berezowska, Gerhard Preissler, Katrin S. Huettl, Alexander Marx, Eric Dominic Roessner, Thomas Graeter |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Pure red cell aplasia 610 Medicine & health autoimmune disease lymphoma thymitis medicine.disease_cause lcsh:RC254-282 Scleroderma Article Autoimmunity surgery 03 medical and health sciences 0302 clinical medicine thymus immune system diseases hemic and lymphatic diseases medicine ddc:610 Autoimmune disease business.industry LESA imaging Hyperplasia lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease myasthenia pathology thymic epithelial tumor Sialadenitis Myasthenia gravis 3. Good health Lymphoma 030104 developmental biology Oncology 030220 oncology & carcinogenesis 570 Life sciences biology business |
| Zdroj: | Cancers, vol. 13, no. 2, pp. 315 Cancers Volume 13 Issue 2 Cancers, Vol 13, Iss 315, p 315 (2021) Porubsky, Stefan; Popovic, Zoran V; Badve, Sunil; Banz, Yara; Berezowska, Sabina; Borchert, Dietmar; Brüggemann, Monika; Gaiser, Timo; Graeter, Thomas; Hollaus, Peter; Huettl, Katrin S; Kotrova, Michaela; Kreft, Andreas; Kugler, Christian; Lötscher, Fabian; Möller, Burkhard; Ott, German; Preissler, Gerhard; Roessner, Eric; Rosenwald, Andreas; ... (2021). Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases. Cancers, 13(2) MDPI AG 10.3390/cancers13020315 |
| Popis: | Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32&ndash 80 lesion diameter 7.0 cm, 1&ndash 14.5 median, range), five (14%) showed associated lymphomas, including four (11%) thymic MALT lymphomas and one (3%) diffuse large B-cell lymphoma. One additional case showed a clonal B-cell-receptor rearrangement without evidence of lymphoma. Twelve (33%) patients (7 women) suffered from partially overlapping autoimmune diseases: systemic lupus erythematosus (n = 4, 11%), rheumatoid arthritis (n = 3, 8%), myasthenia gravis (n = 2, 6%), asthma (n = 2, 6%), scleroderma, Sjö gren syndrome, pure red cell aplasia, Grave&rsquo s disease and anti-IgLON5 syndrome (each n = 1, 3%). Among 11 primary thymic MALT lymphomas, remnants of LESA-like TH were found in two cases (18%). In summary, LESA-like TH shows a striking association with autoimmunity and predisposes to lymphomas. Thus, a hematologic and rheumatologic workup should become standard in patients diagnosed with LESA-like TH. Radiologists and clinicians should be aware of LESA-like TH as a differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases. |
| Databáze: | OpenAIRE |
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