CZH proteins: a new family of Rho-GEFs
| Autor: | Nahum Meller, Sylvain Merlot, Chittibabu Guda |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Dock180 DHR2 domain Dock4 Membrane Proteins Cell Biology GTPase Biology Actin cytoskeleton Cell biology rac GTP-Binding Proteins Cytoskeletal Proteins GTP-binding protein regulators Biochemistry Multigene Family Animals Drosophila Proteins Guanine Nucleotide Exchange Factors Humans Dock9 Guanine nucleotide exchange factor Caenorhabditis elegans Proteins Plant Proteins |
| Zdroj: | Journal of cell science. 118(Pt 21) |
| ISSN: | 0021-9533 |
| Popis: | The Rho family of small GTPases are important regulators of multiple cellular activities and, most notably, reorganization of the actin cytoskeleton. Dbl-homology (DH)-domain-containing proteins are the classical guanine nucleotide exchange factors (GEFs) responsible for activation of Rho GTPases. However, members of a newly discovered family can also act as Rho-GEFs. These CZH proteins include: CDM (Ced-5, Dock180 and Myoblast city) proteins, which activate Rac; and zizimin proteins, which activate Cdc42. The family contains 11 mammalian proteins and has members in many other eukaryotes. The GEF activity is carried out by a novel, DH-unrelated domain named the DOCKER, CZH2 or DHR2 domain. CZH proteins have been implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution. |
| Databáze: | OpenAIRE |
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