Polyamine metabolism in rat lungs with oxygen toxicity
| Autor: | Allen D. Hacker, Thomas K. O'Brien, Donald F. Tierney |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Carboxy-lyases Carboxy-Lyases Biophysics Spermine Lung injury Biology Ornithine Decarboxylase Biochemistry Ornithine decarboxylase chemistry.chemical_compound Internal medicine Polyamines medicine Animals Lung Molecular Biology Oxygen toxicity Rats Inbred Strains Cell Biology medicine.disease Molecular biology Rats Oxygen Spermidine medicine.anatomical_structure Endocrinology chemistry Putrescine |
| Zdroj: | Biochemical and Biophysical Research Communications. 113:491-496 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(83)91752-7 |
| Popis: | Ornithine decarboxylase activity increases 2-fold above control after 1 day and 25-fold after 3 days of exposure to 0.85 atm oxygen. Putrescine content nearly doubled by 72 hours which may reflect increased activity or ornithine decarboxylase. Spermidine and spermine content did not increase until after 3 days of exposure which was consistent with the delayed increase of S-adenosylmethionine decarboxylase activity. The results suggest that antimetabolites of polyamine metabolism may be useful to suppress excessive cellular proliferation in the lung after acute lung injury. |
| Databáze: | OpenAIRE |
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