Feasibility of sentinel node biopsy in head and neck melanoma using a hybrid radioactive and fluorescent tracer

Autor: Omgo E. Nieweg, Fijs W. B. van Leeuwen, Renato A. Valdés Olmos, Oscar R. Brouwer, Lenka Vermeeren, W. Martin C. Klop, Tessa Buckle, Alfons J. M. Balm, Michiel W. M. van den Brekel
Přispěvatelé: Maxillofacial Surgery (AMC), Other departments, AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Adult
Indocyanine Green
Male
Pathology
medicine.medical_specialty
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
SDG 3 - Good Health and Well-being
Biopsy
Fluorescent tracer
Medicine
Humans
In patient
Prospective Studies
Head and neck
Melanoma
Technetium Tc 99m Aggregated Albumin
Aged
Fluorescent Dyes
Neoplasm Staging
Tomography
Emission-Computed
Single-Photon
medicine.diagnostic_test
business.industry
Sentinel Lymph Node Biopsy
Follow up studies
Sentinel node
Middle Aged
medicine.disease
Prognosis
3. Good health
Oncology
chemistry
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Preoperative Period
Feasibility Studies
Surgery
Female
Lymph Nodes
Radiopharmaceuticals
business
Nuclear medicine
Head and Neck Oncology
Indocyanine green
Follow-Up Studies
Zdroj: Annals of Surgical Oncology
Annals of Surgical Oncology, 19(6), 1988-1994. Springer New York
Annals of Surgical Oncology; Vol 19
Brouwer, O R, Klop, W M C, Buckle, T, Vermeeren, L, Van Den Brekel, M W M, Balm, A J M, Nieweg, O E, Valdés Olmos, R A & Van Leeuwen, F W B 2012, ' Feasibility of sentinel node biopsy in head and neck melanoma using a hybrid radioactive and fluorescent tracer ', Annals of Surgical Oncology, vol. 19, no. 6, pp. 1988-1994 . https://doi.org/10.1245/s10434-011-2180-7
Annals of surgical oncology, 19(6), 1988-1994. Springer New York
Annals of Surgical Oncology, 19(6), 1988-1994
ISSN: 1068-9265
DOI: 10.1245/s10434-011-2180-7
Popis: Purpose This study was designed to examine the feasibility of combining lymphoscintigraphy and intraoperative sentinel node identification in patients with head and neck melanoma by using a hybrid protein colloid that is both radioactive and fluorescent. Methods Eleven patients scheduled for sentinel node biopsy in the head and neck region were studied. Approximately 5 h before surgery, the hybrid nanocolloid labeled with indocyanine green (ICG) and technetium-99m (99mTc) was injected intradermally in four deposits around the scar of the primary melanoma excision. Subsequent lymphoscintigraphy and single photon emission computed tomography with computed tomography (SPECT/CT) were performed to identify the sentinel nodes preoperatively. In the operating room, patent blue dye was injected in 7 of the 11 patients. Intraoperatively, sentinel nodes were acoustically localized with a gamma ray detection probe and visualized by using patent blue dye and/or fluorescence-based tracing with a dedicated near-infrared light camera. A portable gamma camera was used before and after sentinel node excision to confirm excision of all sentinel nodes. Results A total of 27 sentinel nodes were preoperatively identified on the lymphoscintigraphy and SPECT/CT images. All sentinel nodes could be localized intraoperatively. In the seven patients in whom blue dye was used, 43% of the sentinel nodes stained blue, whereas all were fluorescent. The portable gamma camera identified additional sentinel nodes in two patients. Ex vivo, all radioactive lymph nodes were fluorescent and vice versa, indicating the stability of the hybrid tracer. Conclusions ICG–99mTc-nanocolloid allows for preoperative sentinel node visualization and concomitant intraoperative radio- and fluorescence guidance to the same sentinel nodes in head and neck melanoma patients. Electronic supplementary material The online version of this article (doi:10.1245/s10434-011-2180-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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