Evaluation of droplet size distributions using univariate and multivariate approaches
| Autor: | Jorgen Wittendorff, Jukka Rantanen, Thomas Vilhelmsen, Mette Høg Gaunø, Crilles Casper Larsen, Jørn Møller-Sonnergaard |
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| Rok vydání: | 2012 |
| Předmět: |
Air Pressure
Principal Component Analysis Multivariate statistics Ethanol Atmospheric pressure Chemistry Drug Compounding Nozzle Analytical chemistry Univariate Pharmaceutical Science General Medicine Factorial experiment Volumetric flow rate Volume (thermodynamics) Multivariate Analysis Principal component analysis Particle Size Cellulose Biological system |
| Zdroj: | Pharmaceutical Development and Technology. 18:926-934 |
| ISSN: | 1097-9867 1083-7450 |
| Popis: | Pharmaceutically relevant material characteristics are often analyzed based on univariate descriptors instead of utilizing the whole information available in the full distribution. One example is droplet size distribution, which is often described by the median droplet size and the width of the distribution. The current study was aiming to compare univariate and multivariate approach in evaluating droplet size distributions. As a model system, the atomization of a coating solution from a two-fluid nozzle was investigated. The effect of three process parameters (concentration of ethyl cellulose in ethanol, atomizing air pressure, and flow rate of coating solution) on the droplet size and droplet size distribution using a full mixed factorial design was used. The droplet size produced by a two-fluid nozzle was measured by laser diffraction and reported as volume based size distribution. Investigation of loading and score plots from principal component analysis (PCA) revealed additional information on the droplet size distributions and it was possible to identify univariate statistics (volume median droplet size), which were similar, however, originating from varying droplet size distributions. The multivariate data analysis was proven to be an efficient tool for evaluating the full information contained in a distribution. |
| Databáze: | OpenAIRE |
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