Sensitivity and specificity of first screen mammography in the Canadian National Breast Screening Study: a preliminary report from five centers
| Autor: | M Petitclerc, B J Shapiro, L Audet, I S Simor, R Jong, C Wall, D V McFarlane, Cornelia J. Baines, D Ouimet-Oliva, Anthony B. Miller |
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| Rok vydání: | 1986 |
| Předmět: |
Canada
medicine.medical_specialty Quality Assurance Health Care Breast Neoplasms law.invention Random Allocation Breast cancer Randomized controlled trial Preliminary report law medicine Humans Breast screening Mammography Radiology Nuclear Medicine and imaging Clinical Trials as Topic medicine.diagnostic_test business.industry Screening Trial Cancer medicine.disease Clinical trial Female Radiology business |
| Zdroj: | Radiology. 160:295-298 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.160.2.3523590 |
| Popis: | Sensitivity and specificity of first screen mammography in a randomized screening trial at five centers are reported. A total of 23,101 women underwent mammography; in 139, breast cancer was detected at first screening; in 20, less than 12 months after first screening; and in 47, at second screening. All 206 cancer cases were histologically confirmed, and 174 were defined as being detectable at first screening. Average length of follow-up for all women was 3.2 years. Interpretations of first screen mammograms by the center radiologists were matched to known outcomes. Simultaneous blind review was performed by a single reference radiologist with mammograms from all 206 cancer cases and those of a random sample of 739 women not known to have breast cancer at 15 months or more after initial screening. Overall, the five screening centers achieved a sensitivity of 69% (range, 60%-78%), a specificity of 94% (range, 93%-96%), a positive predictive value of 8.6% (range, 3%-16%), and a negative predictive value of 99.7% (range, 99.6%-99.9%). |
| Databáze: | OpenAIRE |
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