Solvent-free synthesis of nitrone-containing template as a chemosensor for selective detection of Cu(II) in water
| Autor: | Leonardo M. Carneiro, Fernando H. Bartoloni, Célio F. F. Angolini, Artur F. Keppler |
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| Rok vydání: | 2022 |
| Předmět: |
Detection limit
chemistry.chemical_classification Aqueous solution Chemistry Water Combinatorial chemistry Atomic and Molecular Physics and Optics Analytical Chemistry Nitrone Metal Limit of Detection visual_art Yield (chemistry) Solvents visual_art.visual_art_medium Molecule Nitrogen Oxides Chelation Solubility Instrumentation Spectroscopy |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 267:120473 |
| ISSN: | 1386-1425 |
| Popis: | A state-of-the-art method was developed for repurposing nitrone-containing compounds in the chemosensory field, the ability of the designed molecules to chelate metal cations was evaluated, and their unprecedented solubility in water was confirmed. A facile, rapid, and solvent-free method of synthesizing small molecular mass chemosensors was developed by using a modulative α-aryl-N-aryl nitrone template. α-(Z)-Imidazol-4-ylmethylen-N-phenyl nitrone (Nit1) and α-(Z)-2-pyridyl-N-phenyl nitrone (Nit2) were prepared in 15 min, isolated in less than 60 min with ca. 90% yield, and screened against nine metal cations. Nit1 is a small-molecular-mass compound (188 g mol−1) that is water-soluble and has specificity for sensing Cu2+ with an association constant of K = 1.53 x 1010 and a limit of detection (LOD) of 0.06 ppm. These properties make Nit1 a competitive chemosensor for the detection of Cu2+ in aqueous solution. The nitrone-containing template used in this study is a step forward for new and small chemosensory entities. |
| Databáze: | OpenAIRE |
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