Statistical thermodynamics of the stability of multivalent ligand-receptor complexes

Autor:	E. C. W. Knapp, D. J. Diestler
Rok vydání:	2007
Předmět:	chemistry.chemical_classification Chemistry Ligand Kinetics Molecular Conformation General Physics and Astronomy Thermodynamics Receptors Cell Surface Ligands Divalent Membrane Chemical thermodynamics Models Chemical Mechanism (philosophy) Orders of magnitude (data) Ion channel
Zdroj:	Physical review letters. 100(17)
ISSN:	0031-9007
Popis:	Multivalent ligands can form ligand-receptor complexes that are orders of magnitude more stable than their monovalent counterparts. A theory of this "enhancement effect" based on fundamental principles of statistical thermodynamics is presented. A key finding is a simple analytical expression that provides clear and direct insight into the mechanism by which the enhanced stability of the multivalent ligand-receptor complex can be achieved. The theory explains experimental data on the activation of ion channels in the membranes of cells by polymer-linked divalent ligands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad812346e5167bee77f6690594a88f5e https://pubmed.ncbi.nlm.nih.gov/18518340 Zobrazit plný text záznamu