Efficacy and safety of sublingual fentanyl tablets for the management of breakthrough pain in patients with chronic musculoskeletal pain with neuropathic component: multicenter prospective study
| Autor: | Enrique Domínguez-Suárez, Gustavo Illodo-Miramontes, Pilar Díaz-Parada, Belén García Iglesias, Enrique Freire-Vila, José J. Carceller-Ruiz, Aurora De la Iglesia-López, Beatriz López-Ulloa, Luz Cánovas-Martínez, Alberto Camba-Rodríguez |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Nausea Visual analogue scale Administration Sublingual Pain ladder Fentanyl Quality of life Musculoskeletal Pain Medicine Humans Pharmacology (medical) Prospective Studies Brief Pain Inventory Prospective cohort study Aged Aged 80 and over business.industry Breakthrough Pain General Medicine Middle Aged Physical therapy Neuralgia Female medicine.symptom business Somnolence medicine.drug Tablets |
| Zdroj: | Clinical drug investigation. 35(3) |
| ISSN: | 1179-1918 |
| Popis: | Despite its prevalence and impact, breakthrough pain (BTP) in chronic non-cancer pain with neuropathic component, has not been well studied and is sometimes unrecognized and often undertreated. We evaluated the efficacy of sublingual fentanyl tablet (SLF) for the treatment of BTP in opioid-tolerant patients with chronic musculoskeletal pain with neuropathic component in terms of relief of pain intensity and assessed whether hypothetical pain relief impacts on quality of life (QoL). A multicenter, prospective, open-label study was conducted over a 30-day period. Efficacy was evaluated using a visual analogue scale (VAS) and time to onset of action of SLF. The incidence of dependence was assessed by the Leeds Dependence Questionnaire (LDQ). Changes in QoL were evaluated using the Brief Pain Questionnaire (BPI) and the EuroQol (EQ-5D). Adverse events (AE) were recorded throughout. 106 patients were enrolled and 105 completed the study. The average pain reduction across the study was −3.30 points [95 % confidence interval (CI) 2.9–3.7; P |
| Databáze: | OpenAIRE |
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