Regional myocardial blood flow in stable angina pectoris associated with isolated significant narrowing of either the left anterior descending or left circumflex coronary artery
| Autor: | Gianmario Sambuceti, Lucio Fusani, Piero Salvadori, Giacomo Puccini, Assuero Giorgetti, Oberdan Parodi, Paolo Marzullo, Antonio L'Abbate |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Hemodynamics Coronary Disease Coronary Angiography Angina Pectoris Coronary Circulation Internal medicine medicine Humans Myocardial infarction Circumflex Aged Nitrogen Radioisotopes business.industry Heart Dipyridamole Blood flow Middle Aged medicine.disease Coronary Vessels Myocardial Contraction Vasodilation Coronary arteries Stenosis medicine.anatomical_structure Cardiology Female Cardiology and Cardiovascular Medicine business Perfusion Tomography Emission-Computed medicine.drug |
| Zdroj: | The American Journal of Cardiology. 72:990-994 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(93)90850-c |
| Popis: | Myocardial perfusion measurements were obtained with positron emission tomography under basal conditions and after intravenous dipyridamole infusion (0.56 mg/kg over 4 minutes) to determine if myocardial perfusion is maximized in areas of resting wall motion abnormalities in patients with stable angina. Thirty-three patients with no history of myocardial infarction, and with coronary stenosis50% involving the left anterior descending (n = 24) and left circumflex (n = 9) coronary arteries were evaluated. Quantitative perfusion images were recorded twice in each subject using nitrogen-13 ammonia at baseline and after intravenous administration of dipyridamole. Computer-assisted analysis of left ventriculograms showed abnormal wall motion in the stenosis-related regions in 16 patients (group 1), and normal regional function in 17 (group 2). The flow values in the anterior and posterolateral wall were considered to reflect left anterior and left circumflex coronary artery flow, respectively. Quantitative angiography showed that coronary stenosis severity was higher in group 1 than in group 2 (cross-sectional area reduction 94 +/- 7% vs 87 +/- 11%; p0.05). Resting blood flow in the stenosis-related areas was significantly lower than in contralateral regions in group 1 (0.66 +/- 0.19 vs 0.77 +/- 0.26 ml/min/g; p0.05), but not in group 2 (0.73 +/- 0.18 vs 0.78 +/- 0.21 ml/min/g; p = NS). Dipyridamole significantly (p0.01) increased myocardial blood flow in both stenotic and remote regions in both groups 1 (0.95 +/- 0.41 vs 1.57 +/- 0.70 ml/min/g) and 2 (1.54 +/- 0.53 vs 2.01 +/- 0.84 ml/min/g).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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