The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver
| Autor: | Osama H. Khalil, Ola A. Harb, Osama H Labib, Rham Z. Ahmed, Loay M. Gertallah, Taha A. Baiomy |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Carcinoma Hepatocellular Cirrhosis medicine.medical_treatment Early detection Adenocarcinoma Metastatic carcinoma Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Neoplasm Metastasis neoplasms Early Detection of Cancer Aged Arginase business.industry Liver Neoplasms Gastroenterology Antibodies Monoclonal Cell Differentiation Middle Aged HCCS medicine.disease digestive system diseases Radiation therapy Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Immunohistochemistry Female 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Gastrointestinal Cancer. 51:88-101 |
| ISSN: | 1941-6636 1941-6628 |
| Popis: | Early detection of small HCC and differentiation between HCC from AC metastatic to the liver is very essential for surgical pathologists, due to different treatment modalities. Immunohistochemistry plays a very important role in such conditions. In our study, we aimed to identify the diagnostic benefits of Arginase-1, FTCD& MOC-31 in the early detection of HCC in normal or cirrhotic liver, differentiation between HCC and metastatic ACs to the liver, and for early detection of small micro-metastases from ACs to liver. We included 20 samples from liver cirrhosis, 10 samples from normal liver tissue, 30 samples from primary HCCs in the liver, and 30 samples from metastatic ACs to the liver. We have evaluated Arginase-1, FTCD, and MOC-31 expression using immunohistochemistry. The sensitivity of Arginase-1 expression in differentiation between HCC and metastatic carcinoma was 93.3% and the specificity was 93.3%. The sensitivity of FTCD expression in differentiation between HCC and normal or cirrhotic liver and early detection of well-differentiated HCC was 90% and the specificity was 86.7%. The sensitivity of MOC-31 expression in differentiation between HCC and metastatic carcinoma was 90% and the specificity was 90%. The sensitivity of combination of panel of Arginase 1 + FTCD + MOC 31 expression in differentiation between HCC, metastatic carcinoma, and normal and cirrhotic liver was 93.3% and the specificity was 93.3%. The combination of Arginase 1 + FTCD + MOC 31 expression was helpful in diagnosing most cases of HCC and metastatic carcinoma with high sensitivity and specificity. |
| Databáze: | OpenAIRE |
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