Micronucleus test on quinacrine dihydrochloride in mice: a comparison of dosage regimens
Autor: | M. Hayashi, S. Hitotsumachi, Y. Kimura, M. Ishidate, Y. Nakajima |
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Rok vydání: | 1990 |
Předmět: |
Male
Oral treatment Erythrocytes Bone Marrow Cells Mice Inbred Strains Pharmacology Biology Toxicology Drug Administration Schedule Giemsa stain Mice chemistry.chemical_compound Quinacrine dihydrochloride Bone Marrow Reference Values Genetics Animals Micronuclei Chromosome-Defective Micronucleus Tests Dose-Response Relationship Drug Staining and Labeling Acridine orange Staining Dose–response relationship chemistry Quinacrine Micronucleus test Micronucleus |
Zdroj: | Mutation Research/Environmental Mutagenesis and Related Subjects. 234:141-145 |
ISSN: | 0165-1161 |
DOI: | 10.1016/0165-1161(90)90006-a |
Popis: | Micronucleus induction by quinacrine dihydrochloride (Q) was tested in CD-1 male mice by single, double, and triple oral treatment(s) with 50 or 250 mg/kg. The mice were killed 24 h after the last treatment. Femoral marrow cells were analyzed on slides stained with Giemsa and acridine orange. Both staining methods gave similar results. The frequencies of micronucleated polychromatic erythrocytes (MPE) were marginally increased, in comparison with a concurrent negative control group, only in the triple treatment group of 250 mg/kg. There were, however, no big differences in MPE frequencies among the treatment regimens. |
Databáze: | OpenAIRE |
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