Enantioselective Oxidative Coupling of β-Ketocarbonyls and Anilines by Joint Chiral Primary Amine and Selenium Catalysis
| Autor: | Xueling Mi, Sanzhong Luo, Yanni Wang, Wanting Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Chemistry organic chemicals Organic Chemistry Enantioselective synthesis chemistry.chemical_element Nitroso 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Aldol reaction Reagent Amine gas treating Oxidative coupling of methane Physical and Theoretical Chemistry Selenium |
| Zdroj: | Organic Letters. 21:8178-8182 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | An enantioselective primary amine-catalyzed total N-selective nitroso aldol reaction (N-NA) was achieved through the oxidation of primary aromatic amines to the corresponding nitrosoarenes catalyzed by selenium reagents and 30% H2O2. This protocol provides a facile and highly efficient access to α-hydroxyamino carbonyls bearing chiral quaternary centers under exceedingly mild and green reaction conditions with high chemo- and enantiocontrol. |
| Databáze: | OpenAIRE |
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