Leukocytoclastic Vasculitis; Sequential Appearance of Immunoreactants and Cellular Changes in Serial Biopsies
| Autor: | Richard G. Gower, Henry N. Claman, W. Mitchell Sams, E. George Thorne, Peter F. Kohler |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Injections Intradermal Biopsy Vascular permeability Inflammation Dermatology Immunofluorescence Biochemistry chemistry.chemical_compound Immune system medicine Humans Molecular Biology biology medicine.diagnostic_test Cell Biology Middle Aged medicine.disease Cellular infiltration chemistry Immunology biology.protein Vasculitis Leukocytoclastic Cutaneous Female Antibody medicine.symptom Vasculitis Histamine |
| Zdroj: | Journal of Investigative Dermatology. 69:477-484 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12511631 |
| Popis: | To study the mechanisms responsible for leukocytoclastic vasculitis, we evaluated the kinetics of immunologic and cellular changes in induced vasculitis lesions. In four of five consecutive patients with active vasculitis, lesions were induced by increasing vascular permeability via injecting histamine into the skin. Biopsies were obtained for light and electron microscopy and immunofluorescence at 1, 4, 8, and 24 hr after injection. The results show that immunoglobulin, C3, and electron-dense material are deposited in vessel walls early and are followed by cellular infiltration. The characteristics of the cellular infiltrates were quite diverse at different times after histamine provocation and no distinctive patterns were seen. Nevertheless, the kinetics of the appearance of immunoreactants and cells implies that immunoglobulin and probably circulating immune complexes are present prior to the development of inflammation and supports the contention that deposition of immune complexes within vessel walls is responsible for leukocytoclastic vasculitis. |
| Databáze: | OpenAIRE |
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