Opioid Antagonism, Perceived Exertion and Tolerance to Exercise-Thermal Stress
| Autor: | Hickey Ms, Herbert Wg, Walberg-Rankin J, Lee Jc, Franke Wd |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Mean arterial pressure Hot Temperature medicine.drug_class medicine.medical_treatment Physical Exertion Hemodynamics Physical Therapy Sports Therapy and Rehabilitation Physical exercise (+)-Naloxone chemistry.chemical_compound Oxygen Consumption Opioid receptor Internal medicine Humans Medicine Orthopedics and Sports Medicine Saline Analysis of Variance Naloxone business.industry Forearm Endocrinology chemistry Opioid Anesthesia Receptors Opioid beta-Endorphin business medicine.drug |
| Zdroj: | International Journal of Sports Medicine. 13:326-331 |
| ISSN: | 1439-3964 0172-4622 |
| DOI: | 10.1055/s-2007-1021275 |
| Popis: | In an attempt to investigate the physiological responses to opioid receptor blockade during exercise in the heat, five male volunteers completed two bouts of stationary cycling at 70% VO2max in a hot (33 degrees C765% RH) environment. Exercise was conducted following the administration of either naloxone or saline (4 mg i.v.) five minutes prior to exercise. A second 4 mg dose was administered at 25 minutes of exercise. Performance time was 11% shorter (p = 0.06), and RPE response was significantly higher at test termination on naloxone. No drug effect was observed on rectal or mean skin temperature during exercise. Forearm blood flow (FBF) was higher on naloxone, while exercise heart rates were lower on the drug versus saline. No significant changes were observed in estimated mean arterial pressure or gross sweat responses to exercise. Plasma immunoreactive beta-endorphin was significantly elevated in the naloxone trial only. Thus, while opioids may play some hemodynamic role during exercise in the heat, it appears that opioid mediation of the perceived stress of exercise contributes more to an individual's thermal tolerance. Additionally, the results suggest that perceptual and hemodynamic/cardiovascular responses that may be mediated by these peptides are dissociable phenomena. |
| Databáze: | OpenAIRE |
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