Long-Acting Peptidomimergic Control of Gigantism Caused by Pituitary Acidophilic Stem Cell Adenoma*
| Autor: | Vivien Herman-Bonert, Hrayr Shahinian, Kalman Kovacs, Hiralal G. Maheshwari, Shlomo Melmed, Toni R. Prezant |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Cabergoline Adolescent Antineoplastic Agents Hormonal Adenoma Endocrinology Diabetes and Metabolism Clinical Biochemistry Octreotide Biology Biochemistry Gigantism Endocrinology Pituitary adenoma Internal medicine medicine Humans Somatostatin receptor 2 Pituitary Neoplasms Receptors Somatostatin Ergolines Receptors Dopamine D2 Reverse Transcriptase Polymerase Chain Reaction Stem Cells Adenoma Acidophil Biochemistry (medical) Pituitary tumors medicine.disease Magnetic Resonance Imaging Hormones Somatostatin Delayed-Action Preparations Dopamine Agonists Female medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 85:3409-3416 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.85.9.6824 |
| Popis: | Gigantism is caused by GH hypersecretion occurring before epiphyseal long bone closure and usually is associated with pituitary adenoma. A 15-yr-old female patient presented with accelerated growth due to a large pituitary tumor that was surgically resected to relieve pressure effects. Second surgery to remove residual tumor tissue was followed by administration of octreotide LAR, a long-acting depot somatostatin analog, together with long-acting cabergoline. Height was over the 95th percentile, with evidence of a recent growth spurt. Serum GH levels were more than 60 ng/mL (normal, 8000 ng/mL; normal |
| Databáze: | OpenAIRE |
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