Vascular endothelial growth factor expression and their action in the synovial membranes of patients with painful knee osteoarthritis
| Autor: | Toshihide Matsumoto, Gen Inoue, Dai Iwase, Kentaro Uchida, Jun Aikawa, Masayuki Miyagi, Shotaro Takano, Manabu Mukai, Masashi Takaso |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A 0301 basic medicine medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Gene Expression Pain Neuropeptide Osteoarthritis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Internal medicine Humans Medicine Synovial fluid Orthopedics and Sports Medicine Cells Cultured Aged Pain Measurement Aged 80 and over 030203 arthritis & rheumatology Dose-Response Relationship Drug business.industry Neuropeptides Middle Aged Osteoarthritis Knee Synovial membrane medicine.disease Apelin Vascular endothelial growth factor 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Immunohistochemistry Female lcsh:RC925-935 business Biomarkers Research Article |
| Zdroj: | BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-8 (2018) BMC Musculoskeletal Disorders |
| ISSN: | 1471-2474 |
| Popis: | Background Research suggests that vascular endothelial growth factor (VEGF) levels in the synovial fluid of knee osteoarthritis (KOA) patients are positively correlated with KOA severity. The relationship between synovial VEGF levels and pain in human KOA patients is not fully understood, and the role of VEGF in the pain pathway remains unclear. Methods We harvested synovial membrane (SM) from 102 patients with radiographic evidence of KOA (unilateral Kellgren/Lawrence [K/L] grade 2–4) during total knee arthroplasty. Patients scored their pain on a 0 to 10 cm visual analog scale (VAS). VEGF levels in the SM of KOA patients with strong/severe (VAS ≥ 6) and mild/moderate pain (VAS |
| Databáze: | OpenAIRE |
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