Anticataleptic Effect of Energostim during Single Treatment with Trifluoperazine
| Autor: | E. V. Gurskaya, E. A. Chikobava, P. A. Galenko-Yaroshevskii, G. V. Sukoyan |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Energostim Antioxidant Epinephrine Dopamine medicine.medical_treatment Substantia nigra Trifluoperazine Catalepsy Pharmacology Antioxidants General Biochemistry Genetics and Molecular Biology Norepinephrine Animals Medicine Medulla Oblongata business.industry Dopaminergic General Medicine medicine.disease Dihydroxyphenylalanine Rats Substantia Nigra nervous system Medulla oblongata Cholinergic business Antipsychotic Agents medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 137:255-258 |
| ISSN: | 0007-4888 |
| Popis: | Administration of trifluoperazine in a single dose of 3 mg/kg induced catalepsy and locomotor disorders in 86% intact animals, which persisted for 4 h. Catalepsy developed in only 15% animals pretreated with antihypoxic and antioxidant agent energostim in a dose of 230 mg/kg. The protective effect of energostim was associated with its ability to maintain the balance between dopaminergic, cholinergic, and adrenal activity in the substantia nigra and medulla oblongata during administration of neuroleptics. |
| Databáze: | OpenAIRE |
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