Significance of CA 72.4 serum levels in gastrointestinal diseases
| Autor: | R Polloni, E Daziano, Piantino P, R Mosso, A Fusaro, W Taccone |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty Atrophic gastritis Antibodies Neoplasm Digestive System Diseases Clinical Biochemistry Digestive System Neoplasms Gastroenterology Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen Antigen Predictive Value of Tests Internal medicine medicine Biomarkers Tumor Neoplasm Humans Antigens Tumor-Associated Carbohydrate biology business.industry Cancer Antibodies Monoclonal Middle Aged medicine.disease Carcinoembryonic Antigen 030104 developmental biology Oncology 030220 oncology & carcinogenesis Monoclonal biology.protein Female Differential diagnosis business Gastric Neoplasm |
| Zdroj: | The International journal of biological markers. 5(2) |
| ISSN: | 0393-6155 |
| Popis: | In order to evaluate the usefulness of Ca 72.4 tumor associated antigen assay in gastrointestinal diseases, we have studied 751 patients suffering from benign (376) and neoplastic (375) digestive diseases and 305 normal controls. The cut-off point was fixed at 6 U/ml. The Ca 72.4 assay, with the proposed method, provides additional information only in gastric cancers; the positivity of the marker in gastric neoplasms is 38.4% and the specificity vs gastric ulcers and atrophic gastritis is 99%. In six patients with gastric cancer, the Ca 72.4 is the only positive test. The most striking observation to be made from the current study is a no good sensitivity of the marker for gastrointestinal cancers (29.6% vs 35.7 and 37.6% for CEA and Ca 19-9 respectively), but rather the excellent specificity of the Ca 72.4 immunoassay with respect to beign gastrointestinal diseases (98.7%), vs values of specificity for CEA and Ca 19-9 of 94 and 92%. In conclusion, the high specificity of this marker for gastrointestinal neoplasms may be very interesting in follow-up studies. In fact, an elevation of serum levels of Ca 72.4 should always be taken seriously. |
| Databáze: | OpenAIRE |
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