Dexamethasone is a dose-dependent perpetrator of drug-drug interactions: implications for use in people living with HIV
| Autor: | David Back, Tom G. Jacobs, David M. Burger, Catia Marzolini |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Drug Coronavirus disease 2019 (COVID-19) Dose media_common.quotation_subject Dose dependence Human immunodeficiency virus (HIV) HIV Infections Review Pharmacology medicine.disease_cause Dexamethasone All institutes and research themes of the Radboud University Medical Center In vivo Medicine Cytochrome P-450 CYP3A Humans AcademicSubjects/MED00740 Pharmacology (medical) Drug Interactions media_common CYP3A4 business.industry SARS-CoV-2 COVID-19 Drug Treatment Infectious Diseases AcademicSubjects/MED00290 lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Pharmaceutical Preparations business AcademicSubjects/MED00230 medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy, 77, 568-573 Journal of Antimicrobial Chemotherapy, 77, 3, pp. 568-573 Journal of Antimicrobial Chemotherapy |
| ISSN: | 0305-7453 |
| DOI: | 10.1093/jac/dkab412 |
| Popis: | Global use of dexamethasone in COVID-19 patients has revealed a poor understanding of the drug–drug interaction (DDI) potential of dexamethasone, particularly with antiretroviral agents (ARVs). Dexamethasone is both a substrate and a dose-dependent inducer of cytochrome P450 3A4 (CYP3A4). As many ARVs are substrates and/or inhibitors or inducers of CYP3A4, there is concern about DDIs with dexamethasone either as a perpetrator or a victim. Assessment of DDIs that involve dexamethasone is complex as dexamethasone is used at a range of daily doses (generally 0.5 up to 40 mg) and a treatment course can be short, long, or intermittent. Moreover, DDIs with dexamethasone have been evaluated only for a limited number of drugs. Here, we summarize the available in vitro and in vivo data on the interaction potential of dexamethasone and provide recommendations for the management of DDIs with ARVs, considering various dexamethasone dosages and treatment durations. |
| Databáze: | OpenAIRE |
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