The Effect of Curcumin on the Prevention of Myringosclerosis in Rats
| Autor: | Özlem Akkoca, Hatice Çelik, Nihat Yumuşak, Ramazan Öçal, Selda Kargin Kaytez, Necmi Arslan, Akif Sinan Bilgen, Ali Kavuzlu |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Myringosclerosis 010504 meteorology & atmospheric sciences Rat model animal experiment lcsh:Surgery 01 natural sciences Gastroenterology histology chemistry.chemical_compound Tympanic Membranes Internal medicine Medicine curcumin 0105 earth and related environmental sciences Original Investigation tympanic membrane business.industry Significant difference Histology lcsh:RD1-811 lcsh:Otorhinolaryngology lcsh:RF1-547 rats chemistry Curcumin microscopy business |
| Zdroj: | Turkish Archives of Otorhinolaryngology Turkish Archives of Otorhinolaryngology, Vol 59, Iss 1, Pp 26-32 (2021) |
| ISSN: | 2667-7474 |
| Popis: | Objective: The aim of this study was to investigate the preventative effect of oral curcumin (CMN) on myringosclerosis (MS) in an experimental rat model. Methods: The study included 21 female Wistar albino rats randomly separated into three groups. Group 1 was given no treatment (control group). In Group 2 and Group 3, the tympanic membrane (TM) was perforated using a sterile ear pick. The rats in Group 3 were administered oral CMN 200 mg/kg/day. All rats were sacrificed after 16 days. Otomicroscopic and histopathologic examinations were performed on the tympanic membranes. Results: Histopathologic examinations revealed that there were statistically significant differences between Group 2 and Group 3 in terms of MS degrees (p |
| Databáze: | OpenAIRE |
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