Comparative developmental anatomy of the murine and human definitive placentae

Autor: Georgiades, Pantelis, Fergyson-Smith, A. C., Burton, G. J.
Přispěvatelé: Georgiades, Pantelis [0000-0002-5538-3163]
Rok vydání: 2002
Předmět:
Placenta
genetic analysis
Bioinformatics
Miscarriage
placenta development
Mice
Pregnancy
animal
genetics
cell interaction
Maternal-Fetal Exchange
comparative study
adult
Decidua
Obstetrics and Gynecology
Gene Expression Regulation
Developmental
gene expression regulation
intrauterine growth retardation
placenta disorder
retinoid X receptor alpha
female
spontaneous abortion
medicine.anatomical_structure
priority journal
mouse strain
Female
pregnancy
decidua
human versus animal comparison
Adult
medicine.medical_specialty
placenta
review
prenatal development
blood transfusion
Biology
reproduction
Embryonic and Fetal Development
fetus growth
Species Specificity
glucose transporter 1
Internal medicine
Genetic model
medicine
Animals
Humans
human
giant cell
mouse
Fetus
nonhuman
uterus
vasculotropin
fetomaternal transfusion
species difference
Placentation
Developmental Anatomy
cell type
medicine.disease
trophoblast
Endocrinology
Reproductive Medicine
mother fetus relationship
gene expression
cell structure
Developmental Biology
Zdroj: Placenta
ISSN: 0143-4004
Popis: The placenta of eutherian mammals is a remarkable biological structure. It is composed of both zygote-derived and maternal cells, and mediates the complex interactions between the mother and the fetus that are necessary for fetal growth and survival. While the genetic basis of human placental development and function is largely unknown, its understanding is of immense clinical importance because placentopathies of unknown genetic aetiology are thought to be the cause of many types of pregnancy complications including unexplained miscarriage and intrauterine growth retardation. The mouse is the best-studied mammalian experimental genetic model system and research is not restricted by the inherent ethical and practical limitations associated with the human. As a result, knowledge about the genetic control of mouse placental development has expanded greatly in recent years. In order for this to be of benefit to medical practice, extrapolations from murine to human placentation have to be made. However, comprehensive comparisons of the placentae of these two species are rare. This review therefore compares the developmental anatomy of the placenta between humans and mice with emphasis on structures and cell types that might be analogous between the two species. This could be of particular benefit to mouse developmental geneticists who study placental development and have an interest in the possible clinical implications of their work. © 2002 Harcourt Publishers Ltd. 23 3 19 Cited By :330
Databáze: OpenAIRE
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