Assessment of genotoxic exposure in Swedish coke-oven work by different methods of biological monitoring
| Autor: | Aringer L, Juringe L, Rannug A, Reuterwall C, Elinder Cg, Onfelt A, Levin Jo |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Urinary system Physiology Sister chromatid exchange Urine complex mixtures Toxicology Excretion chemistry.chemical_compound Occupational Exposure Humans Medicine Polycyclic Compounds Carcinogen Mutagenicity Tests business.industry Smoking technology industry and agriculture Public Health Environmental and Occupational Health Carcinogens Environmental Benzo(a)pyrene chemistry Metallurgy Micronucleus test Toxicity business Biomarkers Environmental Monitoring Mutagens |
| Zdroj: | Scandinavian Journal of Work, Environment & Health. 17:123-132 |
| ISSN: | 1795-990X 0355-3140 |
| DOI: | 10.5271/sjweh.1725 |
| Popis: | This study evaluated the results of several biological methods used simultaneously to monitor coke-oven work. Blood samples from 44 male coke-oven workers and 48 male referents, matched for age and smoking/snuff consumption, were examined for cytogenetic damage in lymphocytes. Urinary thioether excretion was determined for 62, and urine mutagenicity for 31, of the subjects, who followed a standardized diet during the urine sampling. Exposure to polycyclic aromatic hydrocarbons varied with work task, the ambient air levels of benzo[a]pyrene sometimes exceeding 5 micrograms/m3. Cytogenetic damage, urine mutagenicity, and thioether excretion did not differ between the groups. The smokers, however, had significantly higher sister chromatid exchange frequencies, urine mutagenicity, and thioether excretion than the nonsmokers. The absence of biological indications of genotoxic exposure was unexpected and indicates that the studied methods are not adequate to assess the carcinogenic risks of Swedish coke-oven workers. |
| Databáze: | OpenAIRE |
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