Epilepsy of infancy with migrating focal seizures: Six patients treated with bromide
| Autor: | Roberto Caraballo, Ernesto Portuondo, María Constanza Pasteris, Pablo Sebastian Fortini |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Bromides
Male Potassium Compounds Clinical Neurology Status epilepticus Potassium bromide Acneiform eruption Focal seizures chemistry.chemical_compound Epilepsy Bromide medicine Humans Child Adverse effect Refractory epilepsy Psychomotor retardation business.industry Epileptic encephalopathy Brain Electroencephalography General Medicine medicine.disease Multifocal seizures Treatment Outcome chemistry Neurology Child Preschool Anesthesia Vomiting Anticonvulsants Female Epilepsies Partial Neurology (clinical) medicine.symptom business Infants |
| Zdroj: | Seizure. 23(10):899-902 |
| ISSN: | 1059-1311 |
| DOI: | 10.1016/j.seizure.2014.06.016 |
| Popis: | Purpose We present six patients with epilepsy of infancy with migrating focal seizures (EIMFS) and provide a comprehensive evaluation of potassium bromide therapy. Method Between February 1, 2007 and July 31, 2012, six patients who met the diagnostic criteria of EIMFS were treated with potassium bromide. Potassium bromide was added to other antiepileptic drugs (AEDs) in doses ranging from 30 to 80mg/kg/day. Plasma bromide concentration was monitored. A therapeutic bromide concentration between 75 and 125mg/dL was considered to be ideal. Results Four of six children responded well to bromide. One of these patients became seizure free, but remained severely mentally impaired. Two boys, currently 4 and 6 years of age, respectively, have monthly seizures as well as axial hypotonia and severe language impairment. The fourth child responded well to bromide, having only weekly seizures and moderate psychomotor retardation. The patient who became seizure free improved visual contact and head control. In the other three patients with good control, the seizures became focal without secondary generalization and status epilepticus and hospital admission was not required. The remaining two patients did not respond well to bromide. Adverse effects were seen in three cases: vomiting in one, drowsiness in another, and acneiform eruption in the face in the remaining patient. Adverse effects resolved with dose reduction. Conclusion Early treatment with bromides should be considered in EIMFS to control the seizures and status epilepticus and to avoid progressive cognitive impairment. Potassium bromide is an old AED. Plasma concentration monitoring should be considered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect