Association of Plasma Marker of Oxidized Lipid with Histologic Plaque Instability in Patients with Peripheral Artery Disease
| Autor: | In Ho Chae, Kichun Kim, Jin Haeng Chung, Gilhyang Kim, Jin Joo Park, Jun Hwan Cho, Jae Sung Choi, Young Seok Cho, Woo Young Chung, Jae Bin Seo, Se Jin Oh, Tae Jin Youn, Dong-Ju Choi, Cheong Lim, Jung Won Suh, Jun Sung Kim |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Statin medicine.drug_class medicine.medical_treatment H&E stain 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging Atherectomy Peripheral Arterial Disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Carotid artery disease Republic of Korea medicine Humans Prospective Studies Aged Endarterectomy Aged 80 and over Rupture Spontaneous business.industry General Medicine Middle Aged Prognosis medicine.disease Plaque Atherosclerotic Up-Regulation Lipoproteins LDL medicine.anatomical_structure Female lipids (amino acids peptides and proteins) Surgery Cardiology and Cardiovascular Medicine business Biomarkers Calcification Lipoprotein Artery |
| Zdroj: | Annals of Vascular Surgery. 66:554-565 |
| ISSN: | 0890-5096 |
| Popis: | Background The association between oxidized low-density lipoprotein (OxLDL) and plaque instability in coronary and carotid artery disease is well established. However, the association between OxLDL and the histologic changes of plaque in peripheral artery disease has not been clearly elucidated. This study aims to investigate the association between plasma OxLDL and histologic plaque instability in patients with peripheral artery disease. Methods Prospectively obtained plaques from 48 patients who underwent endovascular atherectomy (n = 20), surgical endarterectomy (n = 9), or bypass surgery (n = 19) for treatment of atherosclerotic femoropopliteal artery disease were evaluated for histologic fibrosis, sclerosis, calcification, necrosis, cholesterol cleft, and foamy macrophages using hematoxylin and eosin, oil red O, and immunohistochemical staining. Unstable plaques were defined as plaques that were positive for foamy macrophages and with lipid content of more than 10% of the total plaque area. Plasma OxLDL levels were measured using an enzyme-linked immunosorbent assay (Mercodia AB, Uppsala, Sweden). Results Of the 48 patients, 26 (54%) had unstable plaques. The unstable plaque group was younger, had fewer angiographic total occlusions, less calcification, and more CD68-positive and LOX-1-positive cells than the stable plaque group. Plasma OxLDL levels were significantly higher in the unstable plaque group than in the stable plaque group (57.4 ± 13.9 vs. 47.2 ± 13.6 U/L, P = 0.014). Multivariate analysis revealed that plasma OxLDL level, smoking, angiographic nontotal occlusion, and statin nonuse were independent predictors of unstable plaque. Conclusions Among patients with peripheral artery disease, the histologic instability of femoropopliteal plaque was independently associated with high plasma OxLDL, smoking, nontotal occlusion, and statin nonuse. Further large-scale studies are necessary to evaluate the role of noninvasive OxLDL measurement for predicting plaque instability and future adverse vascular event. |
| Databáze: | OpenAIRE |
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