Major Depression and Adverse Patient‐Reported Outcomes in Systemic Lupus Erythematosus: Results From a Prospective Longitudinal Cohort

Autor: Lindsey A. Criswell, Cristina Lanata, Brett W. Dietz, Maria Dall'Era, Patricia P. Katz, Laura Trupin, Jinoos Yazdany, Louise B. Murphy
Rok vydání: 2020
Předmět:
Male
Comorbidity
0302 clinical medicine
Cost of Illness
Quality of life
Epidemiology
Psychology
Lupus Erythematosus
Systemic
Prospective Studies
Depression (differential diagnoses)
Systemic lupus erythematosus
Depression
Pain Research
Middle Aged
Mental Health
Cohort
Public Health and Health Services
Female
Psychosocial
Adult
medicine.medical_specialty
Clinical Sciences
Lupus
Autoimmune Disease
Article
03 medical and health sciences
Rheumatology
Clinical Research
Internal medicine
Behavioral and Social Science
medicine
Humans
Patient Reported Outcome Measures
030203 arthritis & rheumatology
Depressive Disorder
Depressive Disorder
Major
Lupus Erythematosus
business.industry
Inflammatory and immune system
Systemic
Major
medicine.disease
Brain Disorders
Patient Health Questionnaire
Good Health and Well Being
Cross-Sectional Studies
Quality of Life
San Francisco
business
Body mass index
Zdroj: Arthritis Care Res (Hoboken)
Arthritis care & research, vol 73, iss 1
ISSN: 2151-4658
2151-464X
Popis: ObjectiveHealth-related quality of life (HRQoL) is reduced in systemic lupus erythematosus (SLE), partly driven by comorbid depression. Among patients with SLE, the association between major depression and HRQoL, measured using the NIH's Patient-Reported Outcomes Measurement Information System (PROMIS), is not well characterized. The objective was to determine an association between major depression and HRQoL as measured by PROMIS.MethodsCross-sectional data were obtained from the California Lupus Epidemiology Study, a cohort of adults in the San Francisco Bay Area with SLE. We studied the association between major depression (score ≥10 on the Patient Health Questionnaire 8 depression scale) and T scores (scaled to population mean ± SD of 50 ± 10) on 12 PROMIS domains representing physical, mental, and social health. Mean T scores in depressed and nondepressed individuals were compared using multiple linear regression models adjusting for age, sex, race/ethnicity, disease activity, damage, body mass index, and household income.ResultsMean age of the 326 participants was 45 years; ~89% were women, 29% White, 23% Hispanic, 10% African American, and 36% Asian. One-fourth met the criteria for major depression. In multivariable analyses, major depression was independently associated with worse T scores on all 12 PROMIS domains (P < 0.001); compared with those without major depression, depressed individuals scored >10 points (1 SD) worse on fatigue, sleep impairment, negative psychosocial impact of illness, satisfaction in discretionary social activities, and satisfaction in social roles.ConclusionIn individuals with SLE, major depression is associated with markedly worse PROMIS scores in physical, mental, and social domains. Diagnosing and treating depression may help improve HRQoL in individuals with SLE.
Databáze: OpenAIRE
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