Red Blood Cell Membrane Bioengineered Zr-89 Labelled Hollow Mesoporous Silica Nanosphere for Overcoming Phagocytosis
| Autor: | Young Bae Kong, Chirag K. Vyas, Eun Je Lee, Jeong Hoon Park, Pyeong Seok Choi, Seung Dae Yang, Gun Gyun Kim, Jun Young Lee, Min Goo Hur |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biocompatibility Silicon dioxide Phagocytosis lcsh:Medicine Bioengineering Article Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biomimetic Materials In vivo Cell Line Tumor Membrane proteins medicine Animals lcsh:Science Radioisotopes Mice Inbred BALB C Multidisciplinary Erythrocyte Membrane lcsh:R Mesoporous silica Silicon Dioxide Red blood cell 030104 developmental biology medicine.anatomical_structure Membrane chemistry Biophysics Nanoparticles Surface modification Female Cancer imaging lcsh:Q Zirconium Positron-emission tomography Nanospheres 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-43969-y |
| Popis: | Biomimetic nanoparticles (NPs) have been actively studied for their biological compatibility due to its distinguished abilities viz. long-term circulation, low toxicity, ease for surface modification, and its ability to avoid phagocytosis of NPs by macrophages. Coating the NPs with a variety of cell membranes bearing the immune control proteins increases drug efficacy while complementing the intrinsic advantages of the NPs. In this study, efforts were made to introduce oxophilic radiometal 89Zr with hollow mesoporous silica nanospheres (HMSNs) having abundant silanol groups and were bioengineered with red blood cell membrane (Rm) having cluster of differentiation 47 (CD47) protein to evaluate its long-term in vivo behavior. We were successful in demonstrating the increased in vivo stability of synthesized Rm-camouflaged, 89Zr-labelled HMSNs with the markedly reduced 89Zr release. Rm camouflaged 89Zr-HMSNs effectively accumulated in the tumor by avoiding phagocytosis of macrophages. In addition, re-injecting the Rm isolated using the blood of the same animal helped to overcome the immune barrier. This novel strategy can be applied extensively to identify the long-term in vivo behavior of nano-drugs while enhancing their biocompatibility. |
| Databáze: | OpenAIRE |
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