MicroRNAs as key regulators of xenobiotic biotransformation and drug response
| Autor: | Vera Rogiers, Joery De Kock, Tamara Vanhaecke, Mathieu Vinken, Robim Marcelino Rodrigues, Jennifer Bolleyn |
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| Přispěvatelé: | Experimental in vitro toxicology and dermato-cosmetology, Toxicology, Dermato-cosmetology and Pharmacognosy, Pharmaceutical and Pharmacological Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
cytochrome P450 enzymes
Drug-Related Side Effects and Adverse Reactions Health Toxicology and Mutagenesis Receptors Cytoplasmic and Nuclear drug transporters Biology Toxicology Xenobiotics Biological pathway microRNA Transcriptional regulation Animals Humans RNA Messenger Gene Transcription factor General Medicine drug metabolism MicroRNAs Biochemistry Nuclear receptor Gene Expression Regulation Liver Pharmaceutical Preparations Efflux Drug metabolism Transcription Factors |
| Popis: | In the last decade, microRNAs have emerged as key factors that negatively regulate mRNA expression. It has been estimated that more than 50% of protein-coding genes are under microRNA control and each microRNA is predicted to repress several mRNA targets. In this respect, it is recognized that microRNAs play a vital role in various cellular and molecular processes and that, depending on the biological pathways in which they intervene, distorted expression of miRNAs can have serious consequences. It has recently been shown that specific miRNA species are also correlated with toxic responses induced by xenobiotics. Since the latter is primarily linked to the extent of detoxification in the liver accomplished by phase I and phase II biotransformation enzymes and influx and efflux drug transporters, the regulation of the mRNA levels of this particular set of genes through microRNAs is of great importance for the overall toxicological outcome. Consequently, in this paper, an overview of the current knowledge with respect to the complex interplay between microRNAs and the expression of biotransformation enzymes and drug transporters in the liver is provided. Nuclear receptors and transcription factors known to be involved in the transcriptional regulation of these genes are also discussed. |
| Databáze: | OpenAIRE |
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