Effect of Brimonidine Tartrate 0.15% on Scotopic Pupil: Controlled Trial
| Autor: | Vanessa M. Gerente, Augusto Paranhos, Claudio Luiz Lottenberg, Carolina Pelegrini Barbosa, Adriano C. Biondi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male genetic structures Administration Topical medicine.medical_treatment Dark Adaptation Diagnostic Techniques Ophthalmological Pupil law.invention Brimonidine Tartrate Randomized controlled trial law Quinoxalines Adrenergic alpha-2 Receptor Agonists medicine Humans Pharmacology (medical) Scotopic vision Volunteer Antihypertensive Agents Intraocular Pressure Pharmacology business.industry Brimonidine Eye drop eye diseases Ophthalmology Normal volunteers Anesthesia Female sense organs Ophthalmic Solutions business Miotics medicine.drug |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 23:476-480 |
| ISSN: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.2007.0017.r1 |
| Popis: | The aim of this study was to evaluate the duration of the effect of one single dose of brimonidine tartrate 0.15% on pupil diameter, under scotopic conditions, when applied topically in 1 eye of normal subjects.The eyes of 19 normal volunteers were randomized so that 1 eye had 1 drop of brimonidine tartrate 0.15% and the other received no medication. Pupil diameter was measured using an infrared pupillometer. The first measure was obtained before the instillation of brimonidine. After that, four measures, with 2-h intervals, were performed.From 19 participants, 14 were women and 5 were men, with a mean age of 25.05 years (standard deviation, +/- 6.98). Before brimonidine instillation, mean pupil diameter in the control eyes was 5.11 mm, and in the brimonidine eyes it was 5.15 mm. After 8 h, the mean pupil size was 4.01 mm in the treated eyes, and 4.56 mm in the untreated eyes. There was a tendency of miotic effect to be more important on the treated eye, as compared to the control eye in all intervals, but this did not reach statistical significance (P = 0.375). When comparing both eyes, independently of the periods, the treated eye had a smaller diameter than the untreated eye (P = 0.038). The miotic effect was observed for at least 8 h after instillation.Miotic response of brimonidine tartrate 0.15% lasted for at least 8 h and has a significant effect on the nontreated eye. |
| Databáze: | OpenAIRE |
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