Evaluation of Fibrogenic Potential of Industrial Multi-Walled Carbon Nanotubes in Acute Aspiration Experiment
| Autor: | Anna A. Shvedova, R. R. Zalyalov, Liliya M. Fatkhutdinova, Elena R. Kisin, Timur O. Khaliullin |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Connective tissue Inflammation Carbon nanotube medicine.disease_cause Bronchoalveolar Lavage General Biochemistry Genetics and Molecular Biology Article law.invention Transforming Growth Factor beta1 Mice law Fibrosis medicine Animals Osteopontin medicine.diagnostic_test biology Chemistry Nanotubes Carbon General Medicine medicine.disease Mice Inbred C57BL Oxidative Stress Bronchoalveolar lavage medicine.anatomical_structure biology.protein medicine.symptom Cytometry Oxidative stress |
| Popis: | Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers. |
| Databáze: | OpenAIRE |
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