Biotic Supplements in Patients With Chronic Kidney Disease: Meta-Analysis of Randomized Controlled Trials
| Autor: | Jianyong Zhong, GuoLan Xing, Jing Liu, Ying Zhang, Yumeng Yang, Haichun Yang, Valentina Kon, DongQin Wang |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Synbiotics Medicine (miscellaneous) Renal function medicine.disease_cause Gastroenterology Article law.invention chemistry.chemical_compound Randomized controlled trial law Internal medicine medicine Humans Uremic Toxins Renal Insufficiency Chronic Blood urea nitrogen Randomized Controlled Trials as Topic Kidney Creatinine Nutrition and Dietetics business.industry medicine.disease Prebiotics medicine.anatomical_structure chemistry Nephrology business Oxidative stress Kidney disease |
| Zdroj: | J Ren Nutr |
| ISSN: | 1051-2276 |
| DOI: | 10.1053/j.jrn.2021.08.005 |
| Popis: | OBJECTIVE: Gut flora imbalance characterizes patients with chronic kidney disease (CKD). Although biotic supplementation has been proposed to lessen inflammation and oxidative stress and, thus, reduce the risk of progressive kidney damage and cardiovascular disease, the effects remain controversial. We conducted a meta-analysis to assess the therapeutic benefits of biotics in CKD. METHODS: PubMed, Embase, and Cochrane databases were systematically searched for randomized controlled trials that evaluated any biotic (prebiotic, probiotic, synbiotics) supplements in patients with CKD (CKD, stage 3–4 to end-stage renal disease). Primary endpoints included changes in renal function, markers of inflammation, and oxidative stress. Secondary endpoints included changes in levels of uremic toxins and variations in lipid metabolism. RESULTS: Twenty-three eligible studies included 842 participants. In a pooled-analysis, biotics did not change estimated glomerular filtration rate (mean difference [MD] = 0.08, P = .92) or serum albumin (MD = −0.01, P = .86), although prebiotics reduced serum creatinine (standardized mean difference [SMD] = −0.23, P = .009) and blood urea nitrogen (MD = −6.05, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|