Study of E-Cadherin Expression in Normal Oral Mucosa in Oral Precancerous Lesions and in Oral Squamous Cell Carcinomas
| Autor: | Mahendra Singh, Anita Omhare, Vandana Mishra, Lubna Khan, Swetlana Sachan, N. Verma, Anveksha Sachan |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Evidence Based Medicine and Healthcare, Vol 6, Iss 50, Pp 3118-3123 (2019) |
| ISSN: | 2349-2570 2349-2562 |
| Popis: | BACKGROUND Oral cancer is the 11th most common cancer in the world, and death due to this, ranks 6 th globally. India has the highest incidence of oral cancer globally and accounts for approximately 30-40% of all other cancers. Squamous cell carcinoma is the most commonly encountered malignancy of the oral cavity. The most important prognostic factor for patients diagnosed with oral squamous cell carcinoma (OSCC) is metastasis to cervical lymph nodes or distant organs. METHODS This study was carried out among patients attending ENT OPD in LLR Hospital attached to G.S.V.M. Medical College, Kanpur. A detailed clinical history of present illness including relevant past history was recorded and a complete general examination was done. A total of 100 cases diagnosed in histopathology laboratory between July 2017 and August 2019 were included. Expression of E-cadherin was evaluated in normal oral mucosa, oral premalignant lesions and oral squamous cell carcinomas and was correlated with pathological grade. RESULTS There was male preponderance with a male to female ratio of 4.5:1. Maximum cases of oral lesions were encountered in fourth and fifth decades of life. Majority of the cases were tobacco users (85%). CONCLUSIONS Correlation of Squamous Cell Carcinoma cases with the expression of intensity of staining with E-Cadherin was found to be significant with p |
| Databáze: | OpenAIRE |
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