Chronic Chlamydia pneumoniae infection and asthma exacerbations in children
| Autor: | Adam F. Cunningham, Sebastian L. Johnston, Steven A. Julious, M. E. Ward, F. C. Lampe |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pulmonary and Respiratory Medicine
Mycoplasma pneumoniae medicine.disease_cause Asymptomatic Polymerase Chain Reaction medicine Humans Child DNA Fungal Antibodies Fungal Asthma Chlamydia business.industry Respiratory disease Chlamydia Infections Chlamydophila pneumoniae medicine.disease respiratory tract diseases Pneumonia Chronic infection Nasal Mucosa Immunology Chronic Disease medicine.symptom business |
| Zdroj: | The European respiratory journal. 11(2) |
| ISSN: | 0903-1936 |
| Popis: | This study was undertaken to investigate the reported association between Chlamydia pneumoniae and Mycoplasma pneumoniae infection and the expression of asthma-related symptoms. One hundred and eight children with asthma symptoms, aged 9-11 yrs, completed a 13 month longitudinal study. The children maintained a daily diary of respiratory symptoms and peak flow rates. When respiratory symptoms were reported an investigator was called and a nasal aspirate obtained. In total 292 episodes were reported. After the study 65 children provided samples when asymptomatic. The presence of infection was investigated by the polymerase chain reaction for C. pneumoniae and M. pneumoniae and C. pneumoniae secretory immunoglobulin A (IgA) was detected by amplified enzyme immunoassay. C. pneumoniae detections were similar between the symptomatic and asymptomatic episodes (23 versus 28%, respectively). Children who reported multiple episodes also tended to remain PCR positive for C. pneumoniae suggesting chronic infection (p< 0.02). C. pneumoniae-specific secretory-IgA antibodies were more than seven times greater in subjects who reported four or more exacerbations in the study compared to those who reported just one (p |
| Databáze: | OpenAIRE |
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