Similar Survival Following HLA-Identical Sibling Transplantation for Standard Indication in Children with Haematologic Malignancies: A Single Center Comparison of Mobilized Peripheral Blood Stem Cell with Bone Marrow Transplantation
| Autor: | Stefan Balzer, B Bernbeck, Ulrich Göbel, K. Sinha, Roland Meisel, Stefan Schönberger, Christof M. Kramm, Anja Tröger, P. Wernet, Hans-Jürgen Laws, Jürgen Enczmann, Dagmar Dilloo |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Graft failure Adolescent Bone marrow transplantation Graft vs Host Disease PBSC transplantation Human leukocyte antigen Single Center medicine Humans Child Bone Marrow Transplantation Retrospective Studies Gynecology Peripheral Blood Stem Cell Transplantation business.industry Histocompatibility Testing Incidence Patient Selection Siblings Hematopoietic Stem Cell Transplantation Infant Survival Analysis Tissue Donors Surgery Transplantation medicine.anatomical_structure Mobilized Peripheral Blood Stem Cell Child Preschool Data Interpretation Statistical Hematologic Neoplasms Pediatrics Perinatology and Child Health Female Bone marrow business |
| Zdroj: | Klinische Pädiatrie. 217:135-141 |
| ISSN: | 1439-3824 0300-8630 |
| DOI: | 10.1055/s-2005-836509 |
| Popis: | Background: Peripheralblood stem cell (PBSC)g rafts arei ncreasinglyu sed forautologous and allogeneichaemat opoietic stem cell transplantation (alloHSCT)withth e aim toh asten neutrophil and plateletengraftm entand therebyt oreducetransplant-related complicationsdue toi nfections,b leeding and graft failure. Based on the paucity of dataon PBSC transplantation in children w ep erformed aretrospectiv esingle-cente ranalysis comparing the outcome of children receiving mobilized PBSC from humanl e u kocyteantigen (HLA)-identicals ibling donors to bone marro w (BM)transplantr ecipients. Patients and Methods: Between 1996and 2004,16children withh aematologicmalig nanciesand standardi ndication foralloHSCT underwentPBSC transplantation from HLA-identicalsib ling donors.The outcome of thesechildren was compared toahistoricc ontrol groupo f 19 bone marrow(BM)transp lantr ecipients.Time ton eutrophil engraftment,inci denceo facuteand chronicgraft-ver sus-host disease(GvHD) ,relaps erate ,transplant-related mortality, event-free and overall survivalwereanal yzed. Results: Neutrophil engraftmentw asachieved significantlyfas terafterPBSC compared toBM transplantation withamediantime ton eutrophil engraftmentof 11 (range:8‐21) and 19 (16‐44) days fort he PBSC and BMcohort,respectiv ely(p |
| Databáze: | OpenAIRE |
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