Cerebral blood flow alterations specific to auditory verbal hallucinations in schizophrenia
| Autor: | Xiaolei Ma, Jiajia Zhu, Chuanjun Zhuo, Hongru Qu, Wen Qin, Chunshui Yu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cingulate cortex Hallucinations Spin labelling 03 medical and health sciences 0302 clinical medicine Thalamus medicine Humans Right superior temporal gyrus Cerebral Cortex medicine.diagnostic_test business.industry Putamen Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health nervous system Cerebral blood flow Schizophrenia Cerebrovascular Circulation Temporal Regions Visual Perception Female Caudate Nucleus business Neuroscience 030217 neurology & neurosurgery circulatory and respiratory physiology |
| Zdroj: | British Journal of Psychiatry. 210:209-215 |
| ISSN: | 1472-1465 0007-1250 |
| Popis: | BackgroundAuditory verbal hallucinations (AVHs) have been associated with deficits in auditory and speech-related networks. However, the resting-state cerebral blood flow (CBF) alterations specific to AVHs in schizophrenia remain unknown.AimsTo explore AVH-related CBF alterations in individuals with schizophrenia.MethodIn total, 35 individuals with schizophrenia with AVHs, 41 individuals with schizophrenia without AVHs and 50 controls underwent arterial spin labelling magnetic resonance imaging. The CBF differences were voxel-wise compared across the three groups.ResultsWe found AVH-specific CBF increase in the right superior temporal gyrus and caudate, and AVH-specific CBF decrease in the bilateral occipital and left parietal cortices. We also observed consistent CBF changes in both schizophrenia subgroups (i.e. those with and without AVHs) including decreased CBF in the bilateral occipital regions, the left lateral prefrontal and insular cortices, and the right anterior cingulate cortex and increased CBF in the bilateral lateral temporal regions and putamen, the left middle cingulate cortex and the right thalamus.ConclusionsThe AVH-specific CBF increases in the auditory and striatal areas and CBF reductions in the visual and parietal areas suggest that there exists a CBF redistribution associated with AVHs. |
| Databáze: | OpenAIRE |
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