Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update
| Autor: | Mark A. Lovell, Melissa A. Bradley-Whitman |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Lipid Peroxides Health Toxicology and Mutagenesis Disease Toxicology medicine.disease_cause Postmortem Changes Article Lipid peroxidation Pathogenesis chemistry.chemical_compound Alzheimer Disease Predictive Value of Tests medicine Dementia Animals Humans Cognitive Dysfunction Pathological business.industry Brain General Medicine medicine.disease Prognosis Disease Models Animal Early Diagnosis chemistry Disease Progression Autopsy Lipid Peroxidation Alzheimer's disease business Oxidative stress Biomarkers |
| Zdroj: | Archives of toxicology. 89(7) |
| ISSN: | 1432-0738 |
| Popis: | Increasing evidence suggests free radical mediated oxidation of biological substrates is a key feature of Alzheimer’s disease (AD) pathogenesis. While it has long been established that biomarkers of lipid peroxidation (LPO) are elevated in AD brain as well as ventricular CSF postmortem, more recent studies have demonstrated increased LPO biomarkers in postmortem brain from subjects with mild cognitive impairment (MCI), the earliest clinically detectable phase of dementia and preclinical AD (PCAD), the earliest detectable pathological phase. Furthermore, multiple LPO biomarkers are elevated in readily accessible biological fluids throughout disease progression. Collectively these studies demonstrate that LPO is an early feature during disease progression and may be considered a key pathway for targeted therapeutics as well as an enhancer of diagnostic accuracy for early detection of subjects during the prodromal phase. |
| Databáze: | OpenAIRE |
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