Herpesvirus-Induced Antigens in Squamous-Cell Carcinoma in Situ of the Vulva
| Autor: | Gordon R. Dreesman, Joseph L. Melnick, Richard J. Courtney, Matti O. Korhonen, Raymond H. Kaufman, Kenneth L. Powell, Ervin Adam, David O. Matson, Dorothy J. M. Purifoy, Joyce Burek |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Cytoplasm Pathology medicine.medical_specialty Antibodies Viral medicine.disease_cause Vulva Serology Antigen Carcinoma medicine Humans Simplexvirus Antigens Viral Aged Vulvar Neoplasms biology Carcinoma in situ Virion Herpes Simplex DNA General Medicine Middle Aged medicine.disease Virology DNA-Binding Proteins medicine.anatomical_structure Herpes simplex virus Carcinoma Squamous Cell biology.protein Female Vulvar Carcinoma Antibody Carrier Proteins Genital Diseases Female Carcinoma in Situ |
| Zdroj: | New England Journal of Medicine. 305:483-488 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Antigens induced by herpes simplex virus Type 2 (HSV2) were found to be associated with squamous-cell carcinoma in situ of the vulva in nine of 10 patients. The HSV2-induced antigens are DNA-binding proteins that are normally present in the nuclei of infected cells, but in the cells of the carcinomas in situ they were found in the cytoplasm. Whole-virion structural antigens were not present, although there was serologic evidence of previous HSV2 infection in patients tested for the presence of antibodies. The observations reported here and the recent parallel rise in the prevalence of both HSV2 infections and vulvar carcinoma in situ, particularly in women under 40 years of age, suggest an association of HSV2 infection with this type of neoplasia, the nature of which remains to be determined. |
| Databáze: | OpenAIRE |
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